Mechanisms and clinical significance of tumor lymphatic invasion
dc.contributor.author
Fujimoto, Noriki
dc.contributor.author
Dieterich, Lothar C.
dc.date.accessioned
2021-10-14T07:44:59Z
dc.date.available
2021-10-07T04:23:47Z
dc.date.available
2021-10-14T07:44:59Z
dc.date.issued
2021-10
dc.identifier.issn
2073-4409
dc.identifier.other
10.3390/cells10102585
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/508526
dc.identifier.doi
10.3929/ethz-b-000508526
dc.description.abstract
Tumor-associated lymphatic vessels play an important role in tumor progression, medi-ating lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating tumor immunity. An early, necessary step in the lymphatic metastasis cascade is the invasion of lymphatic vessels by tumor cell clusters or single tumor cells. In this review, we discuss our current understanding of the underlying cellular and molecular mechanisms, which include tumor-specific as well as normal, developmental and immunological processes “hijacked” by tumor cells to gain access to the lymphatic system. Furthermore, we summarize the prognostic value of lymphatic invasion, discuss its relationship with local recurrence, lymph node and distant metastasis, and highlight potential therapeutic options and challenges.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Tumor lymphangiogenesis
en_US
dc.subject
Lymphatic invasion
en_US
dc.subject
Metastasis
en_US
dc.subject
Lymph node
en_US
dc.subject
Lymphatic endothelial cell
en_US
dc.title
Mechanisms and clinical significance of tumor lymphatic invasion
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-09-29
ethz.journal.title
Cells
ethz.journal.volume
10
en_US
ethz.journal.issue
10
en_US
ethz.pages.start
2585
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2021-10-07T04:23:50Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-10-14T07:45:13Z
ethz.rosetta.lastUpdated
2022-03-29T14:12:27Z
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true
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Review Article [4008]