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Open access
Date
2021-10Type
- Review Article
Abstract
Tumor-associated lymphatic vessels play an important role in tumor progression, medi-ating lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating tumor immunity. An early, necessary step in the lymphatic metastasis cascade is the invasion of lymphatic vessels by tumor cell clusters or single tumor cells. In this review, we discuss our current understanding of the underlying cellular and molecular mechanisms, which include tumor-specific as well as normal, developmental and immunological processes “hijacked” by tumor cells to gain access to the lymphatic system. Furthermore, we summarize the prognostic value of lymphatic invasion, discuss its relationship with local recurrence, lymph node and distant metastasis, and highlight potential therapeutic options and challenges. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000508526Publication status
publishedExternal links
Journal / series
CellsVolume
Pages / Article No.
Publisher
MDPISubject
Tumor lymphangiogenesis; Lymphatic invasion; Metastasis; Lymph node; Lymphatic endothelial cellMore
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