Transition Metal Ion FRET in the Gas Phase: A 10-40 A Range Molecular Ruler for Mass-Selected Biomolecular Ions
dc.contributor.author
Tiwari, Prince
dc.contributor.author
Wu, Ri
dc.contributor.author
Metternich, Jonas B.
dc.contributor.author
Zenobi, Renato
dc.date.accessioned
2022-07-22T06:51:40Z
dc.date.available
2021-08-20T02:36:55Z
dc.date.available
2021-08-20T05:27:31Z
dc.date.available
2022-02-25T18:58:14Z
dc.date.available
2022-02-28T06:39:05Z
dc.date.available
2022-03-01T09:30:47Z
dc.date.available
2022-04-06T13:04:42Z
dc.date.available
2022-07-22T06:51:40Z
dc.date.issued
2021-08-04
dc.identifier.issn
0002-7863
dc.identifier.issn
1520-5126
dc.identifier.other
10.1021/jacs.1c01915
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/501422
dc.identifier.doi
10.3929/ethz-b-000501422
dc.description.abstract
Structural studies of mass-selected biomolecules in the gas phase can reveal their intrinsic properties and provide useful benchmarks for biomolecular modeling. Here, we report the first evidence of transition metal ion FRET (tmFRET) in the gas phase and its application to measure short (10-40 A) biomolecular backbone distances. The measured FRET efficiencies in rhodamine dye (donor) labeled helical peptides complexed with Cu2+ ions (acceptor) decreased with increasing donor - acceptor distances, confirming the occurrence of tmFRET. The distances estimated for similar peptide sequences from the FRET efficiencies were consistently longer in the gas phase compared to those reported in solution, indicating an expanded structure and a possible loss of helicity.
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application/pdf
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dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.title
Transition Metal Ion FRET in the Gas Phase: A 10-40 A Range Molecular Ruler for Mass-Selected Biomolecular Ions
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2021-07-22
ethz.journal.title
Journal of the American Chemical Society
ethz.journal.volume
143
en_US
ethz.journal.issue
30
en_US
ethz.journal.abbreviated
J. Am. Chem. Soc.
ethz.pages.start
11291
en_US
ethz.pages.end
11295
en_US
ethz.size
5 p.; 6 p. accepted version; 24 p. supporting information
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ethz.version.deposit
acceptedVersion
en_US
ethz.grant
Native Biomolecular Ions in the Gas Physe? A Functional and Structural Approach
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03430 - Zenobi, Renato / Zenobi, Renato
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03430 - Zenobi, Renato / Zenobi, Renato
en_US
ethz.grant.agreementno
ETH-07 15-1
ethz.grant.agreementno
ETH-07 15-1
ethz.grant.agreementno
ETH-07 15-1
ethz.grant.fundername
ETHZ
ethz.grant.fundername
ETHZ
ethz.grant.fundername
ETHZ
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.program
ETH Grants
ethz.grant.program
ETH Grants
ethz.grant.program
ETH Grants
ethz.relation.isSupplementedBy
10.3929/ethz-b-000534351
ethz.date.deposited
2021-08-20T02:37:20Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.date.embargoend
2022-07-21
ethz.rosetta.installDate
2021-08-20T05:28:04Z
ethz.rosetta.lastUpdated
2023-02-07T04:46:42Z
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