Characterization of carbon-coated magnetic nanoparticles using clinical blood coagulation assays
Effect of PEG-functionalization and comparison to silica nanoparticles
dc.contributor.author
Bircher, Lukas
dc.contributor.author
Theusinger, Oliver M.
dc.contributor.author
Locher, Silvan
dc.contributor.author
Eugster, Philipp
dc.contributor.author
Roth-Z'Graggen, Birgit
dc.contributor.author
Schumacher, Christoph M.
dc.contributor.author
Studt, Jan-Dirk
dc.contributor.author
Stark, Wendelin J.
dc.contributor.author
Beck-Schimmer, Beatrice
dc.contributor.author
Herrmann, Inge K.
dc.date.accessioned
2023-07-14T08:02:54Z
dc.date.available
2017-06-11T13:35:58Z
dc.date.available
2023-07-14T08:02:54Z
dc.date.issued
2014-06
dc.identifier.issn
2050-7518
dc.identifier.issn
2050-750X
dc.identifier.other
10.1039/C4TB00208C
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/92018
dc.identifier.doi
10.3929/ethz-b-000092018
dc.description.abstract
Intravascular application of magnetic nanocarriers is a critical step in the development of new therapeutic strategies, including magnetic drug targeting or hyperthermia. However, injection of particulate matter bears the intrinsic risk of contact activation of the blood coagulation cascade. In this work, we use point-of-care assays to study coagulation dynamics and clotting parameters in blood samples exposed to relevant concentrations of surface-functionalized carbon-coated iron carbide nanomagnets using unmodified nanomagnets and poly(ethylene)glycol-functionalized nanomagnets with different end-groups, including –OCH3, –NH2, –COOH, –IgG, and –ProteinA-protected-IgG (–IgG-ProtA). Silica nanoparticles with a comparable surface area are used as a reference material. For magnetic nanoparticles, we observe a decrease in clotting time by 25% compared to native blood at concentrations of 1 mg mL−1, independent of the surface functionalization, and only minor differences in receptor expression on platelets (GP-IIb-IIIa, CD62, and CD63) relative to control samples were observed. Interestingly, the inter-subject variance of the clotting time is similar to the nanoparticle-induced effect in a single subject with average clotting time. Whilst the present study is based on in vitro assays and a small group of healthy blood donors, the comparison to broadly used silica nanoparticles, and the fact that experimental intergroup variability is comparable to the observed effects from the carbon-coated nanomagnets suggests continuing investigations on their potential clinical use.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Royal Society of Chemistry
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Characterization of carbon-coated magnetic nanoparticles using clinical blood coagulation assays
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2014-04-11
ethz.title.subtitle
Effect of PEG-functionalization and comparison to silica nanoparticles
en_US
ethz.journal.title
Journal of Materials Chemistry B
ethz.journal.volume
2
en_US
ethz.journal.issue
24
en_US
ethz.journal.abbreviated
J. Mater. Chem. B
ethz.pages.start
3753
en_US
ethz.pages.end
3758
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007559809
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03673 - Stark, Wendelin J. / Stark, Wendelin J.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03673 - Stark, Wendelin J. / Stark, Wendelin J.
ethz.date.deposited
2017-06-11T13:36:41Z
ethz.source
ECIT
ethz.identifier.importid
imp5936527fd88c326091
ethz.ecitpid
pub:144878
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T13:00:40Z
ethz.rosetta.lastUpdated
2024-02-03T01:41:05Z
ethz.rosetta.versionExported
true
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