Abstract
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000055542Publication status
publishedExternal links
Journal / series
Beilstein Journal of Organic ChemistryVolume
Pages / Article No.
Publisher
Beilstein-Institut zur Förderung der Chemischen WissenschaftenSubject
Automated synthesis; Disaccharide building blocks; Solid-phase; Synthesis; Sialic acid; SialosidesOrganisational unit
03811 - Leroux, Jean-Christophe / Leroux, Jean-Christophe
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ETH Bibliography
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