Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
Abstract
SignificanceB cell clonal selection and expansion from a genetically diverse antibody repertoire guides the immune response to a target antigen. It remains unclear if clonal selection and expansion follow any deterministic rules or are stochastic with regards to phenotypic antibody properties such as antigen-binding, affinity, and epitope specificity. We perform the in-depth genotypic and phenotypic characterization of antibody repertoires following immunization in mice. We identify the degree to which clonal expansion is driven by antibody binding, affinity, and epitope specificity and as such may provide greater insight into vaccine-induced immunity. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000546964Publication status
publishedExternal links
Journal / series
Proceedings of the National Academy of Sciences of the United States of AmericaVolume
Pages / Article No.
Publisher
National Academy of SciencesOrganisational unit
03625 - Oxenius, Annette / Oxenius, Annette
03952 - Reddy, Sai / Reddy, Sai
Related publications and datasets
Is new version of: http://hdl.handle.net/20.500.11850/528646
More
Show all metadata