Evolution and functional cross-talk of protein post-translational modifications
dc.contributor.author
Beltrao, Pedro
dc.contributor.author
Bork, Peer
dc.contributor.author
Krogan, Nevan J.
dc.contributor.author
van Noort, Vera
dc.date.accessioned
2022-02-18T20:54:58Z
dc.date.available
2022-02-10T11:52:03Z
dc.date.available
2022-02-18T20:54:58Z
dc.date.issued
2013-01-01
dc.identifier.issn
1744-4292
dc.identifier.other
10.1002/msb.201304521
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/531913
dc.identifier.doi
10.3929/ethz-b-000531913
dc.description.abstract
Protein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTMs that were spurred by these technological improvements. We provide an overview of studies focusing on the origin and evolution of regulatory enzymes as well as the evolutionary dynamics of modification sites. Finally, we discuss different mechanisms of altering protein activity via post-translational regulation and progress made in the large-scale functional characterization of PTM function.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
EMBO Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject
acetylation
en_US
dc.subject
evolution
en_US
dc.subject
phosphorylation
en_US
dc.subject
post-translational
en_US
dc.title
Evolution and functional cross-talk of protein post-translational modifications
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
dc.date.published
2013-12-20
ethz.journal.title
Molecular Systems Biology
ethz.journal.volume
9
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Mol Syst Biol
ethz.pages.start
714
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Heidelberg
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::09758 - Beltrao, Pedro / Beltrao, Pedro
en_US
ethz.date.deposited
2022-02-10T11:52:09Z
ethz.source
BATCH
ethz.eth
no
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-02-18T20:55:19Z
ethz.rosetta.lastUpdated
2022-03-29T19:34:27Z
ethz.rosetta.versionExported
true
ethz.COinS
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Journal Article [130890]