Abstract
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis. Show more
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https://doi.org/10.3929/ethz-b-000501216Publication status
publishedExternal links
Journal / series
Nature NeuroscienceVolume
Pages / Article No.
Publisher
NatureMore
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