Open access
Date
2021-04Type
- Review Article
Abstract
Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where supramolecular binding motifs are being used in the design of drug delivery systems: engineering network mechanics and tailoring drug–material affinity. Throughout, we highlight many of the established and emerging chemistries or binding motifs that are useful for the design of supramolecular hydrogels for drug delivery applications. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000472329Publication status
publishedExternal links
Journal / series
Advanced Drug Delivery ReviewsVolume
Pages / Article No.
Publisher
ElsevierSubject
Supramolecular hydrogel; Shear-thinning; In situ gelation; Self-assembly; Controlled release; Drug–matrix affinityOrganisational unit
09472 - Tibbitt, Mark / Tibbitt, Mark
Funding
184697 - Next-generation moldable gels via combined polymer-colloid self-assembly and supramolecular chemistry (SNF)
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