Carbonyl Sulfide as a Prebiotic Activation Agent for Stereo- and Sequence-Selective, Amyloid-Templated Peptide Elongation
Abstract
Prebiotic chemical replication is a commonly assumed precursor to and prerequisite for life and as such is the one of the goals of our research. We have previously reported on the role that short peptide amyloids could have played in a template-based chemical elongation. Here we take a step closer to the goal by reproducing amyloid-templated peptide elongation with carbonyl sulfide (COS) in place of the less-prebiotically relevant carbonyldiimidazole (CDI) used in the earlier study. Our investigation shows that the sequence-selectivity and stereoselectivity of the amyloid-templated reaction is similar for both activation chemistries. Notably, the amyloid protects the peptides from some of the side-reactions that take place with the COS-activation. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000418765Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Origins of Life and Evolution of BiospheresBand
Seiten / Artikelnummer
Verlag
SpringerThema
Origin of life; Carbonyl sulfide; Amyloid; Templated peptide synthesisOrganisationseinheit
03782 - Riek, Roland / Riek, Roland
Anmerkungen
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.