Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories
Abstract
Background
Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories.
Methods
We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4–6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity.
Results
Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62–0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4–6.5 and ≥7, respectively.
Conclusions
Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000413627Publication status
publishedExternal links
Journal / series
Multiple Sclerosis and Related DisordersVolume
Pages / Article No.
Publisher
ElsevierSubject
EDSS; Registries; Patient reported outcome; Self-report; Proxy measureMore
Show all metadata