Open access
Date
2020-04-03Type
- Review Article
ETH Bibliography
yes
Altmetrics
Abstract
Neuronal activity is the main contributor to the high‐energy demand of the human brain. ATP is needed for the maintenance of ionic gradients, neurotransmitter transport, and release, as well as the signaling pathways that follow activation of post‐synaptic receptors. The inability to maintain a high supply of ATP through tight regulatory mechanisms can, therefore, have severe consequences for brain function. In this issue of EMBO Reports, Cui et al [1] show that pharmacological inhibition or genetic inactivation of CD39, an ectonucleotide tri(di)phosphohydrolase responsible for converting ATP into AMP, has antidepressant‐like effects by maintaining high extracellular ATP levels in the presence of stress. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000455506Publication status
publishedExternal links
Journal / series
EMBO ReportsVolume
(4)Pages / Article No.
Publisher
EMBO PressOrganisational unit
09498 - Schratt, Gerhard / Schratt, Gerhard
Funding
179651 - Der Beitrag umweltbedingt induzierter, globaler Veränderungen der mikroRNA-Biogenese zur Entstehung affektiver Störungen (SNF)
189486 - Altered Translation in Autism (ALTRUISM) (SNF)
More
Show all metadata
ETH Bibliography
yes
Altmetrics