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dc.contributor.author
Blocquiaux, Sara
dc.contributor.author
Gorski, Tatiane
dc.contributor.author
Van Roie, Evelien
dc.contributor.author
Ramaekers, Monique
dc.contributor.author
Van Thienen, Ruud
dc.contributor.author
Nielens, Henri
dc.contributor.author
Delecluse, Christophe
dc.contributor.author
De Bock, Katrien
dc.contributor.author
Thomis, Martine
dc.date.accessioned
2020-02-14T11:00:26Z
dc.date.available
2020-02-14T03:22:37Z
dc.date.available
2020-02-14T11:00:26Z
dc.date.issued
2020-05
dc.identifier.other
10.1016/j.exger.2020.110860
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/399361
dc.identifier.doi
10.3929/ethz-b-000399361
dc.description.abstract
Introduction Ageing is associated with an attenuated hypertrophic response to resistance training and periods of training interruptions. Hence, elderly would benefit from the ‘muscle memory’ effects of resistance training on muscle strength and mass during detraining and retraining. As the underlying mechanisms are not yet clear, this study investigated the role of myonuclei during training, detraining and retraining by using PCM1 labelling in muscle cross-sections of six older men. Methods Knee extension strength and power were measured in 30 older men and 10 controls before and after 12 weeks resistance training and after detraining and retraining of similar length. In a subset, muscle biopsies from the vastus lateralis were taken for analysis of fibre size, fibre type distribution, Pax7+ satellite cell number and myonuclear domain size. Results Resistance training increased knee extension strength and power parameters (+10 to +36%, p < .001) and decreased the frequency of type IIax fibres by half (from 20 to 10%, p = .034). Detraining resulted in a modest loss of strength and power (−5 to −15%, p ≤ .004) and a trend towards a fibre-type specific decrease in type II fibre cross-sectional area (−17%, p = .087), type II satellite cell number (−30%, p = .054) and type II myonuclear number (−12%, p = .084). Less than eight weeks of retraining were needed to reach the post-training level of one-repetition maximum strength. Twelve weeks of retraining were associated with type II fibre hypertrophy (+29%, p = .050), which also promoted an increase in the number of satellite cells (+72%, p = .036) and myonuclei (+13%, p = .048) in type II fibres. Changes in the type II fibre cross-sectional area were positively correlated with changes in the myonuclear number (Pearson's r between 0.40 and 0.73), resulting in a stable myonuclear domain. Conclusion Gained strength and power and fibre type changes were partially preserved following 12 weeks of detraining, allowing for a fast recovery of the 1RM performance following retraining. Myonuclear number tended to follow individual changes in type II fibre size, which is in support of the myonuclear domain theory.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Muscle memory
en_US
dc.subject
Muscle hypertrophy
en_US
dc.subject
Muscle atrophy
en_US
dc.subject
Myonuclear domain
en_US
dc.subject
Pax7
en_US
dc.subject
PCM1
en_US
dc.title
The effect of resistance training, detraining and retraining on muscle strength and power, myofibre size, satellite cells and myonuclei in older men
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2020-02-01
ethz.journal.title
Experimental Gerontology
ethz.journal.volume
133
en_US
ethz.pages.start
110860
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::09560 - De Bock, Katrien / De Bock, Katrien
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::09560 - De Bock, Katrien / De Bock, Katrien
ethz.relation.isReferencedBy
handle/20.500.11850/417525
ethz.date.deposited
2020-02-14T03:22:50Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-02-14T11:00:37Z
ethz.rosetta.lastUpdated
2021-02-15T08:03:34Z
ethz.rosetta.versionExported
true
ethz.COinS
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