Carbonyl Sulfide as a Prebiotic Activation Agent for Stereo- and Sequence-Selective, Amyloid-Templated Peptide Elongation
Abstract
Prebiotic chemical replication is a commonly assumed precursor to and prerequisite for life and as such is the one of the goals of our research. We have previously reported on the role that short peptide amyloids could have played in a template-based chemical elongation. Here we take a step closer to the goal by reproducing amyloid-templated peptide elongation with carbonyl sulfide (COS) in place of the less-prebiotically relevant carbonyldiimidazole (CDI) used in the earlier study. Our investigation shows that the sequence-selectivity and stereoselectivity of the amyloid-templated reaction is similar for both activation chemistries. Notably, the amyloid protects the peptides from some of the side-reactions that take place with the COS-activation. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000418765Publication status
publishedExternal links
Journal / series
Origins of Life and Evolution of BiospheresVolume
Pages / Article No.
Publisher
SpringerSubject
Origin of life; Carbonyl sulfide; Amyloid; Templated peptide synthesisOrganisational unit
03782 - Riek, Roland / Riek, Roland
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
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