Systemic sclerostin antibody treatment increases osseointegration and biomechanical competence of zoledronic-acid-coated dental implants in a rat osteoporosis model
dc.contributor.author
Korn, Paula
dc.contributor.author
Kramer, Ina
dc.contributor.author
Schlottig, Falko
dc.contributor.author
Tödtmann, Ninette
dc.contributor.author
Eckelt, Uwe
dc.contributor.author
Bürki, Alexander
dc.contributor.author
Ferguson, Stephen J.
dc.contributor.author
Kautz, Armin
dc.contributor.author
Schnabelrauch, Matthias
dc.contributor.author
Range, Ursula
dc.contributor.author
Kneissel, Michaela
dc.contributor.author
Stadlinger, Bernd
dc.date.accessioned
2019-08-07T08:07:00Z
dc.date.available
2019-08-07T02:34:29Z
dc.date.available
2019-08-07T08:07:00Z
dc.date.issued
2019-05-21
dc.identifier.issn
1473-2262
dc.identifier.other
10.22203/eCM.v037a20
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/356990
dc.identifier.doi
10.3929/ethz-b-000356990
dc.description.abstract
Osseointegration of dental implants can be promoted by implant-surface modifications using bisphosphonate coatings. In addition, it is of clinical interest to promote peri-implant bone formation and to restore bony structure in low bone-mass patients. The present study evaluated a combination of an anti-resorptive zoledronic acid (ZOL) implant-coating and a systemically applied sclerostin antibody, a known bone anabolic treatment principle, versus sole sclerostin antibody treatment or ZOL implant-coating in a rat osteoporosis model.
Uncoated reference surface implants or ZOL-coated implants (n = 64/group) were inserted into the proximal tibia of aged osteoporotic rats three months following ovariectomy. 32 animals of each group received once weekly sclerostin antibody therapy. Osseointegration was assessed 2 or 4 weeks post-implantation by ex vivo µCT, histology and biomechanical testing.
Overall implant survival rate was 97 %. Histomorphology revealed pronounced bone formation along the entire implant length of ZOL-coated implants. At 4 weeks following implant insertion, bone-implant contact, cancellous bone mineral density and bone volume/tissue volume were significantly increased for the combination of ZOL and sclerostin antibody as compared to sclerostin antibody or ZOL implant-coating alone. Removal torque was also significantly increased in the combination therapy group relative to animals receiving only sclerostin antibody therapy or ZOL-coated implants.
In an osteoporotic rat model, the combination of anti-resorptive ZOL implant-coating and systemically applied sclerostin antibody led to significantly increased peri-implant bone formation. Therefore, the combination of ZOL and the osteoanabolic sclerostin antibody was more effective than either agent alone.
en_US
dc.format
application/pdf
en_US
dc.language.iso
de
en_US
dc.publisher
AO Research Institute Davos
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-sa/4.0/
dc.subject
Dental implant
en_US
dc.subject
Osseointegration
en_US
dc.subject
Osteoporosis animal model
en_US
dc.subject
Sclerostin antibody
en_US
dc.subject
Zoledronic acid
en_US
dc.title
Systemic sclerostin antibody treatment increases osseointegration and biomechanical competence of zoledronic-acid-coated dental implants in a rat osteoporosis model
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-ShareAlike 4.0 International
ethz.journal.title
European Cells & Materials
ethz.journal.volume
37
en_US
ethz.journal.abbreviated
Eur Cell Mater
ethz.pages.start
333
en_US
ethz.pages.end
346
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Davos
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03915 - Ferguson, Stephen / Ferguson, Stephen
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03915 - Ferguson, Stephen / Ferguson, Stephen
ethz.date.deposited
2019-08-07T02:34:33Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-08-07T08:07:13Z
ethz.rosetta.lastUpdated
2023-02-06T17:29:04Z
ethz.rosetta.versionExported
true
ethz.COinS
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