CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
dc.contributor.author
Zawadzka, Malgorzata
dc.contributor.author
Rivers, Leanne E.
dc.contributor.author
Fancy, Stephen P.J.
dc.contributor.author
Zhao, Chao
dc.contributor.author
Tripathi, Richa
dc.contributor.author
Jamen, Françoise
dc.contributor.author
Young, Kaylene
dc.contributor.author
Goncharevich, Alexander
dc.contributor.author
Pohl, Hartmut
dc.contributor.author
Rizzi, Matteo
dc.contributor.author
Rowitch, David H.
dc.contributor.author
Kessaris, Nicoletta
dc.contributor.author
Suter, Ueli
dc.contributor.author
Richardson, William D.
dc.contributor.author
Franklin, Robin J.M.
dc.date.accessioned
2024-08-09T08:30:42Z
dc.date.available
2017-06-08T23:57:32Z
dc.date.available
2024-08-09T08:30:42Z
dc.date.issued
2010-06-04
dc.identifier.issn
1934-5909
dc.identifier.issn
1875-9777
dc.identifier.other
10.1016/j.stem.2010.04.002
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/20592
dc.description.abstract
After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.title
CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
en_US
dc.type
Journal Article
dc.date.published
2010-06-03
ethz.journal.title
Cell Stem Cell
ethz.journal.volume
6
en_US
ethz.journal.issue
6
en_US
ethz.pages.start
578
en_US
ethz.pages.end
590
en_US
ethz.identifier.wos
ethz.publication.place
Cambridge, MA
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03367 - Suter, Ulrich / Suter, Ulrich
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03367 - Suter, Ulrich / Suter, Ulrich
ethz.date.deposited
2017-06-08T23:57:56Z
ethz.source
ECIT
ethz.identifier.importid
imp59364cbb5b06342507
ethz.ecitpid
pub:33096
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-26T04:08:05Z
ethz.rosetta.lastUpdated
2018-10-01T08:39:55Z
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true
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