Open access
Date
2022-11-04Type
- Working Paper
ETH Bibliography
yes
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Abstract
Morphogen gradients can instruct cells about their position in a patterned tissue. Non-linear morphogen decay has been suggested to increase gradient precision by reducing the sensitivity to variability in the morphogen source. Here, we use cell-based simulations to quantitatively compare the positional error of gradients for linear and non-linear morphogen decay. While we confirm that non-linear decay reduces the positional error close to the source, the reduction is very small for physiological noise levels. Far from the source, the positional error is much larger for non-linear decay in tissues that pose a flux barrier to the morphogen at the boundary. In light of this new data, a physiological role of morphogen decay dynamics in patterning precision appears unlikely. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000590935Publication status
publishedExternal links
Journal / series
bioRxivPublisher
Cold Spring Harbor LaboratorySubject
Morphogen gradient; Tissue patterning; Precision; Non-linear decay; Cell-based simulationOrganisational unit
03791 - Iber, Dagmar / Iber, Dagmar
Funding
170930 - A 3D Cell-Based Simulation Framework for Morphogenetic Problems (SNF)
Related publications and datasets
Is supplemented by: https://git.bsse.ethz.ch/iber/Publications/2022_adelmann_vetter_nonlinear_decay
Is previous version of: https://doi.org/10.3929/ethz-b-000610021
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ETH Bibliography
yes
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