1. <i>In silico</i> medical device testing of anatomically and mechanically conforming patient-specific spinal fusion cages designed by full-scale topology optimisation 

   Smit, Thijs; Aage, Niels; Haschtmann, Daniel; et al. (2024)

   Frontiers in Bioengineering and Biotechnology

   A full-scale topology optimisation formulation has been developed to automate the design of cages used in instrumented transforaminal lumbar interbody fusion. The method incorporates the mechanical response of the adjacent bone structures in the optimisation process, yielding patient-specific spinal fusion cages that both anatomically and mechanically conform to the patient, effectively mitigating subsidence risk compared to generic, ...

   Journal Article

2. <i>In Situ</i> Observation of Topotactic Linker Reorganization in the Aperiodic Metal-Organic Framework TRUMOF-1 

   Greenbaum, Guy; Doheny, Patrick W.; Paraoan, Robert A. I.; et al. (2024)

   Journal of the American Chemical Society

   We use in situ synchrotron X-ray diffraction measurements to monitor the solvothermal crystallization mechanism of the aperiodic metal-organic framework TRUMOF-1. Following an initial incubation period, TRUMOF-1 forms as a metastable intermediate that subsequently transforms into an ordered product with triclinic crystal symmetry. We determine the structure of this ordered phase, which we call msw-TRUMOF-1, and show that it is related to ...

   Journal Article

3. Finding non-fluorinated alternatives to fluorinated gases used as refrigerants 

   Gluge, Juliane; Breuer, Katharina; Hafner, Armin; et al. (2024)

   Environmental Science: Processes & Impacts

   Hydrofluorocarbons (HFCs) and so-called hydrofluoroolefins (HFOs) are used as refrigerants in air conditioning, refrigeration, chillers, heat pumps and devices for dehumidification and drying. However, many HFCs, including R-134a and R-125, have a high global warming potential and some of the HFCs and HFOs degrade atmospherically and form trifluoroacetic acid (TFA) as a persistent degradation product. Rising levels of TFA around the globe ...

   Review Article

4. How effective are ecological metrics in supporting conservation and management in degraded streams? 

   Mathers, Kate L.; Robinson, Christopher T.; Hill, Matthew; et al. (2024)

   Biodiversity and Conservation

   Biodiversity loss is increasing worldwide, necessitating effective approaches to counteract negative trends. Here, we assessed aquatic macroinvertebrate biodiversity in two river catchments in Switzerland; one significantly degraded and associated with urbanisation and instream barriers, and one in a near-natural condition. Contrary to our expectations, environmental heterogeneity was lower in the near-natural stream, with enhanced ...

   Journal Article

5. Precise Size Determination of Supported Catalyst Nanoparticles via Generative AI and Scanning Transmission Electron Microscopy 

   Eliasson, Henrik; Lothian, Angus; Surin, Ivan; et al. (2024)

   Small Methods

   Transmission electron microscopy (TEM) plays a crucial role in heterogeneous catalysis for assessing the size distribution of supported metal nanoparticles. Typically, nanoparticle size is quantified by measuring the diameter under the assumption of spherical geometry, a simplification that limits the precision needed for advancing synthesis-structure-performance relationships. Currently, there is a lack of techniques that can reliably ...

   Journal Article

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