Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2
Abstract
The B cell response to diferent pathogens uses tailored efector mechanisms and results in functionally specialized memory B (Bₘ) cell subsets, including CD21⁺ resting, CD21⁻CD27⁺ activated and CD21⁻CD27⁻Bₘ cells. The interrelatedness between these Bₘ cell subsets remains unknown. Here we showed that single severe acute respiratory syndrome coronavirus 2-specifc Bₘ cell clones showed plasticity upon antigen rechallenge in previously exposed individuals. CD21⁻Bₘ cells were the predominant subsets during acute infection and early after severe acute respiratory syndrome coronavirus 2-specifc immunization. At months 6 and 12 post-infection, CD21⁺ resting Bₘ cells were the major Bₘ cell subset in the circulation and were also detected in peripheral lymphoid organs, where they carried tissue residency markers. Tracking of individual B cell clones by B cell receptor sequencing revealed that previously fated Bₘ cell clones could rediferentiate upon antigen rechallenge into other Bₘ cell subsets, including CD21⁻CD27⁻Bₘ cells, demonstrating that single Bₘ cell clones can adopt functionally diferent trajectories. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000613290Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Nature ImmunologyBand
Seiten / Artikelnummer
Verlag
NatureOrganisationseinheit
09711 - Moor, Andreas / Moor, Andreas
Zugehörige Publikationen und Daten
Is referenced by: https://doi.org/10.3929/ethz-b-000631093