Biology, vulnerabilities and clinical applications of circulating tumour cells
dc.contributor.author
Ring, Alexander
dc.contributor.author
Nguyen-Sträuli, Bich Doan
dc.contributor.author
Wicki, Andreas
dc.contributor.author
Aceto, Nicola
dc.date.accessioned
2023-03-14T14:44:10Z
dc.date.available
2023-01-07T07:37:02Z
dc.date.available
2023-01-23T09:49:51Z
dc.date.available
2023-03-14T14:44:10Z
dc.date.issued
2023-02
dc.identifier.issn
1474-175X
dc.identifier.issn
1471-175X
dc.identifier.other
10.1038/s41568-022-00536-4
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/590816
dc.description.abstract
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm-changing, liquid biopsy-based clinical applications. Analysis of CTCs has revealed distinct biological phenotypes, including the presence of CTC clusters and the interaction between CTCs and immune or stromal cells, impacting metastasis formation and providing new insights into cancer vulnerabilities. Here we review the progress made in understanding biological features of CTCs and provide insight into exploiting these developments to design future clinical tools for improving the diagnosis and treatment of cancer.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
en_US
dc.title
Biology, vulnerabilities and clinical applications of circulating tumour cells
en_US
dc.type
Review Article
dc.date.published
2022-12-09
ethz.journal.title
Nature Reviews Cancer
ethz.journal.volume
23
en_US
ethz.journal.issue
2
en_US
ethz.pages.start
95
en_US
ethz.pages.end
111
en_US
ethz.grant
Tumor-lock: forbid the generation of circulating tumor cells
en_US
ethz.grant
Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity.
en_US
ethz.grant
CRISPR screen for immunotherapy sensitizers in humanized circulating tumor cell xenografts
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::09736 - Aceto, Nicola / Aceto, Nicola
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::09736 - Aceto, Nicola / Aceto, Nicola
ethz.grant.agreementno
101001652
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801159-21
ethz.grant.agreementno
212183
ethz.grant.fundername
EC
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
H2020
ethz.grant.program
H2020
ethz.grant.program
Projekte Lebenswissenschaften
ethz.date.deposited
2023-01-07T07:37:08Z
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WOS
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yes
en_US
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Metadata only
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2023-03-14T14:44:11Z
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2023-03-14T14:44:11Z
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Review Article [3967]