Biology, vulnerabilities and clinical applications of circulating tumour cells
Metadata only
Datum
2023-02Typ
- Review Article
Abstract
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm-changing, liquid biopsy-based clinical applications. Analysis of CTCs has revealed distinct biological phenotypes, including the presence of CTC clusters and the interaction between CTCs and immune or stromal cells, impacting metastasis formation and providing new insights into cancer vulnerabilities. Here we review the progress made in understanding biological features of CTCs and provide insight into exploiting these developments to design future clinical tools for improving the diagnosis and treatment of cancer. Mehr anzeigen
Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Nature Reviews CancerBand
Seiten / Artikelnummer
Verlag
NatureOrganisationseinheit
09736 - Aceto, Nicola / Aceto, Nicola
Förderung
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