Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
Abstract
SignificanceB cell clonal selection and expansion from a genetically diverse antibody repertoire guides the immune response to a target antigen. It remains unclear if clonal selection and expansion follow any deterministic rules or are stochastic with regards to phenotypic antibody properties such as antigen-binding, affinity, and epitope specificity. We perform the in-depth genotypic and phenotypic characterization of antibody repertoires following immunization in mice. We identify the degree to which clonal expansion is driven by antibody binding, affinity, and epitope specificity and as such may provide greater insight into vaccine-induced immunity. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000546964Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Proceedings of the National Academy of Sciences of the United States of AmericaBand
Seiten / Artikelnummer
Verlag
National Academy of SciencesOrganisationseinheit
03625 - Oxenius, Annette / Oxenius, Annette
03952 - Reddy, Sai / Reddy, Sai
Zugehörige Publikationen und Daten
Is new version of: http://hdl.handle.net/20.500.11850/528646