A role for the cortex in sleep-wake regulation
dc.contributor.author
Krone, Lukas B.
dc.contributor.author
Yamagata, Tomoko
dc.contributor.author
Blanco-Duque, Cristina
dc.contributor.author
Guillaumin, Mathilde C.C.
dc.contributor.author
Kahn, Martin C.
dc.contributor.author
van der Vinne, Vincent
dc.contributor.author
McKillop, Laura E.
dc.contributor.author
Tam, Shu K. E.
dc.contributor.author
Peirson, Stuart N.
dc.contributor.author
Akerman, Colin J.
dc.contributor.author
Hoerder-Suabedissen, Anna
dc.contributor.author
Molnar, Zoltan
dc.contributor.author
Vyazovskiy, Vladyslav V.
dc.date.accessioned
2021-09-03T12:35:14Z
dc.date.available
2021-08-18T02:37:02Z
dc.date.available
2021-09-03T12:35:14Z
dc.date.issued
2021-09
dc.identifier.issn
1097-6256
dc.identifier.issn
1546-1726
dc.identifier.other
10.1038/s41593-021-00894-6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/501216
dc.identifier.doi
10.3929/ethz-b-000501216
dc.description.abstract
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
A role for the cortex in sleep-wake regulation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-08-02
ethz.journal.title
Nature Neuroscience
ethz.journal.volume
24
en_US
ethz.journal.abbreviated
Nat. neurosci.
ethz.pages.start
1210
en_US
ethz.pages.end
1215
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.date.deposited
2021-08-18T02:37:29Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-09-03T12:35:21Z
ethz.rosetta.lastUpdated
2024-02-02T14:37:29Z
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true
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Journal Article [129998]