Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C–H Amination
Open access
Date
2021-02-19Type
- Journal Article
Abstract
We report both an intermolecular C–H amination of arenes to access N-methylanilines and an intramolecular variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000468727Publication status
publishedExternal links
Journal / series
Organic LettersVolume
Pages / Article No.
Publisher
American Chemical SocietyOrganisational unit
09634 - Morandi, Bill / Morandi, Bill
Funding
184658 - Catalytic synthesis of unprotected amines and heterocycles (SNF)
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