Resistance training preserves high-intensity interval training induced improvements in skeletal muscle capillarization of healthy old men: a randomized controlled trial
dc.contributor.author
Leuchtmann, Aurel B.
dc.contributor.author
Müller, Sandro M.
dc.contributor.author
Aguayo, David
dc.contributor.author
Petersen, Jens A.
dc.contributor.author
Ligon-Auer, Maria
dc.contributor.author
Flück, Martin
dc.contributor.author
Jung, Hans H.
dc.contributor.author
Toigo, Marco
dc.date.accessioned
2020-05-04T13:02:24Z
dc.date.available
2020-05-02T18:37:03Z
dc.date.available
2020-05-04T13:02:24Z
dc.date.issued
2020
dc.identifier.issn
2045-2322
dc.identifier.other
10.1038/s41598-020-63490-x
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/412703
dc.identifier.doi
10.3929/ethz-b-000412703
dc.description.abstract
Skeletal muscle capillarization is a determining factor in gas and metabolite exchange, while its impairments may contribute to the development of sarcopenia. Studies on the potential of resistance training (RT) to induce angiogenesis in older muscles have been inconclusive, and effects of sequential endurance training (ET) and RT on capillarization are unknown. Healthy older men (66.5 ± 3.8 years) were engaged in either 12 weeks of habitual course observation (HC) followed by 12 weeks of RT (n = 8), or 12 weeks of high-intensity interval training (HIIT) followed by 12 weeks of RT (n = 9). At baseline, following 12 and 24 weeks, m. vastus lateralis biopsies were obtained. (Immuno-)histochemistry was used to assess indices of muscle fiber capillarization, muscle fiber morphology and succinate dehydrogenase (SDH) activity. Single periods of RT and HIIT resulted in similar improvements in capillarization and SDH activity. During RT following HIIT, improved capillarization and SDH activity, as well as muscle fiber morphology remained unchanged. The applied RT and HIIT protocols were thus similarly effective in enhancing capillarization and oxidative enzyme activity and RT effectively preserved HIIT-induced adaptations of these parameters. Hence, both, RT and HIIT, are valid training modalities for older men to improve skeletal muscle vascularization.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Resistance training preserves high-intensity interval training induced improvements in skeletal muscle capillarization of healthy old men: a randomized controlled trial
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-04-20
ethz.journal.title
Scientific Reports
ethz.journal.volume
10
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Sci Rep
ethz.pages.start
6578
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.date.deposited
2020-05-02T18:37:17Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-05-04T13:02:38Z
ethz.rosetta.lastUpdated
2024-02-02T10:50:44Z
ethz.rosetta.versionExported
true
ethz.COinS
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Journal Article [130181]