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dc.contributor.author
De Simone, Gabriele
dc.contributor.author
Mazza, Emilia M.C.
dc.contributor.author
Cassotta, Antonino
dc.contributor.author
Davydov, Alexey N.
dc.contributor.author
Kuka, Mirela
dc.contributor.author
Zanon, Veronica
dc.contributor.author
De Paoli, Federica
dc.contributor.author
Scamardella, Eloise
dc.contributor.author
Metsger, Maria
dc.contributor.author
Roberto, Alessandra
dc.contributor.author
Pilipow, Karolina
dc.contributor.author
Colombo, Federico S.
dc.contributor.author
Tagliafico, Enrico
dc.contributor.author
Gattinoni, Luca
dc.contributor.author
Mavilio, Domenico
dc.contributor.author
Peano, Clelia
dc.contributor.author
Price, David A.
dc.contributor.author
Singh, Satya P.
dc.contributor.author
Farber, Joshua M.
dc.contributor.author
Serra, Valentina
dc.contributor.author
Cucca, Francesco
dc.contributor.author
Ferrari, Francesco
dc.contributor.author
Orrù, Valeria
dc.contributor.author
Iannacone, Matteo
dc.contributor.author
Chudakov, Dmitriy M.
dc.contributor.author
Sallusto, Federica
dc.contributor.author
Lugli, Enrico
dc.date.accessioned
2019-12-20T16:25:59Z
dc.date.available
2019-12-20T05:54:41Z
dc.date.available
2019-12-20T16:25:59Z
dc.date.issued
2019-12-15
dc.identifier.issn
0022-1767
dc.identifier.issn
1048-3233
dc.identifier.issn
1047-7381
dc.identifier.issn
1550-6606
dc.identifier.other
10.4049/jimmunol.1901072
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/386775
dc.identifier.doi
10.3929/ethz-b-000386775
dc.description.abstract
n mice, the ability of naive T (TN) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8+ TN cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3+ TN cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide–HLA class I Ags. Moreover, CXCR3+ TN cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3+ TN cells were transcriptionally equivalent to murine CXCR3+ TN cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8+ T cells.
en_US
dc.format
application/pdf
en_US
dc.publisher
AAI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
CXCR3 Identifies Human Naive CD8<sup>+</sup> T Cells with Enhanced Effector Differentiation Potential
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-12-09
ethz.journal.title
The Journal of Immunology
ethz.journal.volume
203
en_US
ethz.journal.issue
12
en_US
ethz.journal.abbreviated
J Immunol
ethz.pages.start
3179
en_US
ethz.pages.end
3189
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Bethesda, MD
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::09604 - Sallusto, Federica / Sallusto, Federica
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::09604 - Sallusto, Federica / Sallusto, Federica
ethz.date.deposited
2019-12-20T05:54:52Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-12-20T16:26:09Z
ethz.rosetta.lastUpdated
2022-03-29T00:30:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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