CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion
Abstract
Magic-angle spinning (MAS) is mandatory in solid-state NMR experiments to achieve resolved spectra. In rare cases, instabilities in the rotation or damage of either the rotor or the rotor cap can lead to a so called “rotor crash” involving a disintegration of the sample container and possibly the release of an aerosol or of dust. We present a modified design of a 3.2 mm probe with a confining chamber which in case of a rotor crash prevents the release of aerosols and possibly hazardous materials. 1D and 2D NMR experiments show that such a hazardous material-confining MAS probe (“CONFINE-MAS” probe) has a similar sensitivity compared to a standard probe and performs equally well in terms of spinning stability. We illustrate the CONFINE-MAS probe properties and performance by application to a fungal amyloid. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000313278Publication status
publishedJournal / series
Journal of Biomolecular NMRVolume
Pages / Article No.
Publisher
SpringerSubject
Solid-state NMR; Magic-angle spinning; Safety; ContainmentOrganisational unit
03496 - Meier, Beat H. (emeritus) / Meier, Beat H. (emeritus)
Funding
159707 - NMR studies in the Solid State (SNF)
741863 - Faster magic-angle spinning leads to a resolution revolution in biological solid-state NMR (EC)
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
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