Open access
Autor(in)
Alle anzeigen
Datum
2011-03-16Typ
- Journal Article
ETH Bibliographie
yes
Altmetrics
Abstract
Recent findings suggest that pain and pleasure share common neurochemical circuits, and studies in animals and humans show that opioid-mediated descending pathways can inhibit or facilitate pain. We explored the role of endogenous opioid neurotransmission in pleasure-related analgesia. μ-Opioidergic activity was blocked with 0.2 mg/kg naloxone to assess its effects on hedonic responses to pleasant emotional pictures (International Affective Picture System) and its modulating effects on heat pain tolerance. Naloxone did not alter subjective and autonomous reactions to pleasure induction or overall mood of participants. In addition, pleasure-related increases in pain tolerance persisted after reversal of endogenous μ-opioidergic neurotransmission. Subjective pain intensity and unpleasantness ratings increased after naloxone administration. These findings suggest that, in addition to opioid-sensitive circuits, mainly opioid-insensitive pain-modulating circuits are activated during pleasure-related analgesia. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-a-006783528Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
The Journal of NeuroscienceBand
Seiten / Artikelnummer
Verlag
Society for NeuroscienceOrganisationseinheit
02803 - Collegium Helveticum / Collegium Helveticum
03325 - Folkers, Gerd (emeritus)
ETH Bibliographie
yes
Altmetrics