Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics
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Datum
2016-09Typ
- Journal Article
ETH Bibliographie
no
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Abstract
A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to simultaneously deal with the antibiotic-induced damage and maintain rapid growth. We found that the treated cells increased energy production, as well as translation and macromolecular repair and protection. These responses are adaptive, because they confer increased survival not only to lethal ampicillin treatment but also to non-antibiotic lethal stresses. This robustness is modulated by nutrient availability. Because different antibiotics and other stressors induce the same set of responses, we propose that it constitutes a general core hormetic stress response. It is plausible that this response plays an important role in the robustness of bacteria exposed to antibiotic treatments and constant environmental fluctuations in natural environments. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000125266Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Cell ReportsBand
Seiten / Artikelnummer
Verlag
ElsevierThema
Antibiotics; Sublethal stress; Hormetic stress response; General stress response; RpoS; Stringent response; PpGpp; Energy metabolism; Translation; Escherichia coliOrganisationseinheit
03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ETH Bibliographie
no
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