1. Waves of regulated protein expression and phosphorylation rewire the proteome to drive gametogenesis in budding yeast 

   Wettstein R.; Hugener J.; Gillet L.; et al. (2024)

   Developmental Cell

   Sexually reproducing eukaryotes employ a developmentally regulated cell division program—meiosis—to generate haploid gametes from diploid germ cells. To understand how gametes arise, we generated a proteomic census encompassing the entire meiotic program of budding yeast. We found that concerted waves of protein expression and phosphorylation modify nearly all cellular pathways to support meiotic entry, meiotic progression, and gamete ...

   Journal Article

2. Inferring maximum magnitudes from the ordered sequence of large earthquakes 

   Schultz R. (2024)

   Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

   The largest magnitude earthquake in a sequence is often used as a proxy for hazard estimates, as consequences are often predominately from this single event (in small seismic zones). In this article, the concept of order statistics is adapted to infer the maximum magnitude ([Formula: see text]) of an earthquake catalogue. A suite tools developed here can discern [Formula: see text] influences through hypothesis testing, quantify [Formula: ...

   Journal Article

3. <i>SwissGenVar</i>: A Platform for Clinical-Grade Interpretation of Genetic Variants to Foster Personalized Healthcare in Switzerland 

   Kraemer, Dennis; Terumalai, Dillenn; Famiglietti, Maria Livia; et al. (2024)

   JOURNAL OF PERSONALIZED MEDICINE

   Large-scale next-generation sequencing (NGS) germline testing is technically feasible today, but variant interpretation represents a major bottleneck in analysis workflows. This includes extensive variant prioritization, annotation, and time-consuming evidence curation. The scale of the interpretation problem is massive, and variants of uncertain significance (VUSs) are a challenge to personalized medicine. This challenge is further ...

   Journal Article

4. The Radiation Therapist profession through the lens of new technology: A practice development paper based on the ESTRO Radiation Therapist Workshops 

   Leech, Michelle; Abdalqader, Alaa; Alexander, Sophie; et al. (2024)

   TECHNICAL INNOVATIONS & PATIENT SUPPORT IN RADIATION ONCOLOGY

   Technological advances in radiation therapy impact on the role and scope of practice of the radiation therapist. The European Society of Radiotherapy and Oncology (ESTRO) recently held two workshops on this topic and this position paper reflects the outcome of this workshop, which included radiation therapists from all global regions. Workflows, quality assurance, research, IGRT and ART as well as clinical decision making are the areas ...

   Journal Article

5. Effects of wall roughness on low-level outlet performance 

   Pagliara, S.; Hohermuth, B.; Felder, S.; et al. (2023)

   ROLE OF DAMS AND RESERVOIRS IN A SUCCESSFUL ENERGY TRANSITION, ECS 2023

   Reservoir dams play a key role in modern society, water resources management and economy. Low-level outlets (LLOs) represent important safety structures for regulating the water level in the reservoir, and for its fast drawdown in case of scheduled maintenance or emergency situations. The flow in LLO tunnels is characterized by high velocities and turbulence levels, leading to air entrainment and transport. This results in sub-atmospheric ...

   Conference Paper

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