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Author
Date
2024Type
- Journal Article
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Abstract
Due to their efficient production of reactive oxygen species (ROS) under visible light irradiation, fullerenes (C₆₀ and C₇₀) are useful photosensitizers for applications in photodynamic therapy (PDT). To be suitable as medicines, water-soluble fullerene materials were developed by complexation or conjugation with biocompatible polymers such as poly(vinylpyrrolidone) (PVP) and polyethylene glycol (PEG), and their ROS generation abilities were investigated. In addition, a C₆₀-tripod molecule was synthesized for the modification of AFM tips and used for spatially and temporally controlled oxidative damage of DNA origami immobilized on the surface. Show more
Publication status
publishedExternal links
Journal / series
Journal of Synthetic Organic Chemistry, JapanVolume
Pages / Article No.
Publisher
Society of Organic Synthetic Chemistry, JapanFunding
140451 - AFM probe functionalization with synthetic tips for single molecule chemical force microscopy (SNF)
156097 - Synthesis and Study of Photoexcited Fullerenes (SNF)
173018 - Bright and smart MRI contrast agents (SNF)
215394 - Precise, Localized Oxidation of Surfaces with Synthetic, Photocatalytic AFM Tips (SNF)
183660 - Porphyrin-based imaging probe for the detection of oncogene promoter quadruplex DNA (SNF)
ETH-21 15-2 - MRI probe for the in vivo imaging of atherosclerosis (ETHZ)
ETH-45 19-1 - Spatially and temporally controlled manipulation of DNA origami by chemically modified AFM tip (ETHZ)
ETH-36 20-2 - ROS-responsive MRI probe for in vivo imaging (ETHZ)
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